Explor Neurosci. 2022;1:4–30 DOI: https://doi.org/10.37349/en.2022.00002
https://www.explorationpub.com/Journals/en/Article/10062
Abstract
All living organisms exhibit circadian rhythms. Humans show circadian rhythm of the different physiological functions such as sleep-wake cycle, core body temperature, feeding behavior, metabolic activity, heart rate variability, hormone secretion, and others. The hypothalamic suprachiasmatic nucleus (SCN) acts as a primary circadian pacemaker. Peripheral tissues have an endogenous circadian clock; however, SCN synchronizes the circadian activity of the peripheral clocks. The retinohypothalamic tract (RHT) from retinal ganglionic cells carries the photic signal into the SCN that regulates the rhythmic expression of the core clock genes through the feedback loop. At the output level, the SCN connects with the pineal gland and the peripheral tissues with the help of neuroendocrine mediators. Disruption of circadian clock functions is detrimental to health. Shift work, night work, chronic or acute jet lag, and light-at-night have adverse effects on circadian functions. Misalignment of circadian rhythm alters the expression of core clock genes, leading to deregulation of cellular activity and metabolic functions. Circadian rhythm dysfunction causes many pathologic conditions, including sleep disorders, cardiovascular problems, metabolic dysfunction, infertility, poor physical performance, as well as cancer. The present work has reviewed the relationship between circadian clock dysfunction and impaired physiological activities.
Excerpt:
The circadian system acts as a biological timekeeper and regulates physiological functions throughout the day in relation to environmental time cues. The primary activity of the circadian system occurs within the SCN, which makes synchronization with the endogenous peripheral clocks. SCN receives a light-associated impulse from the retina that governs the expression of the core clock genes. Misalignment in the circadian rhythm adversely affects human health. There are many anthropogenic causes of circadian clock dysfunction; these include rotating shift work, night work, exposure to bright light-at-night, chronic jet lag, and modern lifestyle. Circadian dysfunction influences the development of sleep problems, neurodegenerative diseases, psychological illness, metabolic syndrome (diabetes, dyslipidemias, obesity, etc.), cardiovascular disorder, and cancer. In recent times, these disorders are the major public health issues and people are facing serious problems in this concern.
Cubit Calculator Notes:
Key relevance to circadian function and clock gene expression can be found in the following post: BP45 In The Blink Of An Eye
Photonic Laser Light Point Signaling Precision
Just like the stars in the sky and the flowers gracing our feet, our bodies are quantum solar generators, and sunlight is our natural power source. The frequency and amplitude of sunlight we receive, primarily through the eyes, skin, and mitochondria regulate our psychological and physiological state individually and via collective time and temperature ScHUMANn entrainment. Beyond visual information transmission, the optical pathway is also responsible for hypothalamic circadian regulation. The pupillary reflex is responsible for the balance between the two branches of our body’s automatic control center, the sympathetic and parasympathetic nervous system. To achieve homeostatic balance, photonic solar stream tuning must precisely sync between sending and receiving spectral frequency coordinates to correctly transmit signaling instruction.
Given that our global metrology standards aren’t synchronized with our natural solar cycling rhythms, it is becoming abundantly clear that the hyperpolarization in the rhythmic interference patterns is contributing to the light flickering we are experiencing, altering our collective state of consciousness…
This continued exploration expounds on our remembrance of how circadian light signaling cycles provide the key to unlocking full genetic expression through electromagnetic alignment. Through the following contributions, we pay tribute to the studies of Richard Feynman, and all the other equally brilliant minds, lighting the path back to focus on the celestial solar cycles powering the electrical signaling network underlying our material forms.